This the sequel of 2000 film The Adventures of Rocky and Bullwinkle, Karen's uncle has been capture by a new villain who replace Boris and Natasha, so Karen team up again with Rocky, Bullwinkle, Boris and Natasha.
After the narrator review what happen last time in the first movie of The Adventures of Rocky and Bullwinkle, Rocky and Bullwinkle begin to search of a beautiful cheerleader wolf, Snowball with a help of three of their old friends Captain Peter Wrong-Way Peachfuzz and the two moon man, Gidney and Cloyd, together when they were looking for her , they see Fearless Leader, Boris and Natasha had her tie up, so Rocky, Bullwinkle, Captain Peachfuzz, Gidney and Cloyd fight Fearless Leader, Boris and Natasha to rescue Snowball, than called the police and arrested the three villains, after that in the real world, Karen Sympathy and her prisons guard boyfriend, Ole begin to love this movie.
15 years later, Karen and Ole are married and have their daughter, Pandora, but Karen's uncle John Sympathy came for a surprise on her 8th birthday, John told his great niece that when her mother was a little girl she have her real parents, Burdine and Neil Sympathy and they love Karen so much until John's arch-enemy, Doctor Arthur Prisons and his sidekick, Lucina Angelle L'Awfully came and destroy Burdine and Neil, then John came to rescue Karen and beat up Prisons and Lucina Angelle. Pandora told her great uncle that she is sorry to hear about Karen's parents.
In the Republic of Chipan, Ming-Huaxing's cousin Zhang-Ye-Qi Risusabi, a young flying squirrel sorceress and Rocky's cousin's Micheal J. Squirrel's immortal ancestral close friend (before her) playing with her pipa until she hear Doctor Arthur Prisons and his sidekick Lucina Angelle escape from jail and free Fearless Leader, Boris and Natasha in America. Zhang-Ye-Qi also hear after Dr. Prisons and Lucina Angelle free the three villains, Fearless Leader offer them to help him take over America, but Boris and Natasha told Fearless Leader that they don't trust that Prisons , he is tricking, then Fearless Leader got into a argument with Boris and Natasha then told them don't help him anymore. Then Boris and Natasha left Fearless Leader alone with Dr. Prisons and Luncina Angelle. Then Zhang-Ye-Qi also hear those villains plan to capture John Sympathy so she fly to Karen for help.
Meanwhile, Dr. Prisons , Lucina Angelle and the three villains meets his second sidekick named Jonathan Samuel Unjustly and told that they kill Karen's parents, capture John Sympathy and free Fearless Leader, Boris and Natasha from American prison, but Boris and Natasha still distraught about Dr. Prisons plan to get ride of Huaxing's cousin, Rocky and Bullwinkle so Fearless Leader is angry at them for treating Prisons that so he fired Boris and Natasha, then he hired Dr. Prisons, Lucina Angelle and Jonathan Samuel to be his new spies. Back at Sympathy Manners, John told Karen that he is the best agents in the world but when Karen try to tell her uncle something Lucina Angelle and Jonathan come by and begin to capture John, when Karen try to save him Lucina Angelle tie her to the chair and then they left with out Karen, Pandora came in and see her mother tie up, so she untie Karen, then Zhang-Ye-Qi came and tell Karen that Dr. Prisons escape and free Fearless Leader, Boris and Natasha.
Karen told Pandora not to tell her father about her mission and she promise. So Karen and Zhang-Ye-Qi left and go to Los Angeles to get Rocky and Bullwinkle help. Later, Karen and Zhang-Ye-Qi arrives in Los Angeles, but Zhang-Ye-Qi said "My cousin and her sidekick's spells have magic powers, but i must absolutely use my magic like them." As they made it they find lighthouse when Karen got Rocky and Bullwinkle to the real world with green light, so she and Zhang-Ye-Qi did the same thing like Karen did. They went in and press Fantasy Adventure and Road Comedy then they tap "The Rocky and Bullwinkle Movie" then they pull the rake, then the green light begin to bring Rocky and Bullwinkle to the real world again. Rocky and Bullwinkle are glad to see Karen again, Zhang-Ye-Qi told them that Karen has an uncle named John Sympathy has been captured by Fearless Leader, Dr. Prisons, Lucina Angelle and Jonathan Samuel. Rocky and Bullwinkle didn't realizes Fearless Leader has been free by Dr. Prisons and took Boris and Natasha's place, so they team up with Karen and Zhang-Ye-Qi because the new bad guys were replaced Boris and Natasha. But Zhang-Ye-Qi said that her cousin Huaxing and Shanying were been also captured by Dr. Prison and they're also her immortal sorceress-sifu/sensei mistresses .
Meanwhile, Dr. Prisons , Lucina Angelle and Jonathan Samuel tie John to the chair and he didn't that Fearless Leader who from the Rocky and Bullwinkle Show is helping Dr. Prisons take over America and also capture Huaxing and Shanying who got tie up too. But Ming-Huaxing and Bei-Shanying glared to Dr. Prison what they are captured John Sympathy and them and take over America and leaving Boris and Natasha, but Dr. Prison said that beacause he is made it to take over the country and he's captured them. So Ming-Huaxing and Bei-Shanying gasped and ask Fearless Leader and Dr. Prison why are they doing this to them and John, Fearless Leader told them that he, Dr. Prison , Lucina Angelle and Jonathan Samuel are going to turn John into a cartoon, but John demand those villains to let him, Huaxing and Shanying go, but they wouldn't so they got plan for them.
When Rocky, Bullwinkle , Karen and Zhang-Ye-Qi are on their way, they find Boris and Natasha whose told them that they've been replaced by Dr. Prison , Lucina Angelle and Jonathan Samuel, so Boris and Natasha decide to be on Rocky, Bullwinkle , Karen and Zhang-Ye-Qi's side (just like in Boris and Natasha: The Movie! when they were good guys) then they agree with that. When Karen's dad, Neil's sister's daughter, Fern Sympathy along with Bei-Shanying's cousin Zhen-Kuai-Lin Musujika, a young antlered moose sorceress and also a former detective discovers Zhang-Ye-Qi and said that they've meet Rocky's siblings Mia and Furry and Bullwinkle's girlfriend Blaineley the last time. They told Rocky, Bullwinkle , Karen, Boris, Natasha and Zhang-Ye-Qi that Fearless Leader and Dr. Prison plan to turn John in to a cartoon character then they're going to do same thing to Fern and then Karen, then she , Rocky, Bullwinkle , Boris, Natasha and Zhang-Ye-Qi are not going to let that happen so they join Fern and Zhen-Kuai-Lin on detetives. But Zhen-Kuai-Lin said that they're not detectives and she is not a detective, she is a witch and Zhang-Ye-Qi understand her and smiled at her .
Back at Sympathy Manners Pandora told her father a lie (like her mother tell her not to tell the truth) that Karen and her uncle are on a trip, but Ole is still worry about his wife so much so Pandora ask her father that it is going to be a father and daughter time. But Pandora told to him that they're now parents and daughter.
Later at Dr. Prison's lare, he, Fearless Leader, Lucina Angelle and Jonathan Samuel hear a message that Boris and Natasha are on Rocky, Bullwinkle and Karen's side now because Fearless Leader fire them, then he got angry and told John that he, Prison , Lucina and Jonathan will deal with him later. Fearless Leader told Prison and his henchman to kill Moose, Squirrel, Badenov, Miss Fatale and John niece the FBI lady immediately, including his younger niece. But John told Fearless Leader that those villains can't do this to Karen and Fern just like Dr. Prison kill her parents, Ming-Huaxing and Bei-Shanying told to Prisons what Fearless Leader has abandonned his two spies and help him to take over everything. They said that they need their cousins and wuxia/magic and sorcery students to save them, they find a solution to untied themselves, then they said that Rocky, Bullwinkle and the rest will need of them.
Meanwhile, Rocky, Bullwinkle , Karen, Boris, Natasha, Fern, Zhang-Ye-Qi and Zhen-Kuai-Lin were driving on the road until Dr. Prison , Lucina Angelle and Jonathan Samuel use some bomb to kill but seven heroes jump out just like 15 years ago when Karen's old yellow car has been destroyed. Zhang-Ye-Qi worried her sifu / sensei mistress and Zhen-Kuai-Lin too, they told to Karen thay they all rights like 15 years past. But Karen and Fern look at Prisons , Jonathan Samuel and Lucina Angelle care a type of cannon and lights it but the witches's cousins Fern and Karen off the fire from the cannon. Then, the witches cousins and the rest steals the truck from Prisons and his sidekicks, when Dr. Prisons Jonathan Samuel, Lucina Angelle saw the manuel book and read it.
When they call Fearless Leader, Lucina Angelle and Jonathan Samuel calls him that they've Mooses, Squirrels, Mr. Badenov, Miss Fatale and Pandora's mother escape, but Fearless Leader is very angry to he told them that they're next plan to capture Karen and Fern Sympathy so he can turn them and their uncle into a cartoon. John told Fearless Leader that he and Prison will never get away with this. Fearless Leader told him that he already have then he see Huaxing and Shanying escape.
Back on the road Rocky, Bullwinkle , the witches cousins and the rest were still drive ith Prison's truck, but Rocky ask to Karen and Fern they cannot driving on a stealing truck and could turning their uncle into a toon like this. Zhang-Ye-Qi sighs that she and Zheng-Kuai-Lin must fin their cousin sifu / sensei mistresses , Huaxing and Shanying whose escape from Dr. Prison's lare and told Zhang-Ye-Qi, Zheng-Kuei-Lin, Rocky, Bullwinkle , Karen, Fern, Boris and Natasha that Fearless Leader plan to kill them and also capture Karen and Fern to turn them and their uncle into a cartoon, then Karen and Fern are not going to let that happen. Then her Chinese sorcerer and Huaxing and Shanying's old friend Ka-Lun Tongqing came to help and he already know Karen and Fern about 17 years ago. Together Zhang-Ye-Qi, Zheng-Kuei-Lin, Ming-Huaxing, Bei-Shanying and Ka-Lun use their powers to make Prison's truck fly so he, Lucina and Jonathan won't go after them.
Back at Sympathy Manners, Ole calls a hotel managers that he would like to speak to his wife, Karen, but the managers did not know Karen and her uncle so he hang up. Now Ole know the truth so he ask Pandora were is her mother. Pandora told her father that she promise her mother not to tell him that she on a mission to rescue her uncle from Dr. Arthur Prison with a help from Fearless Leader, Ole already know that Fearless Leader is from The Rocky and Bullwinkle Show, so he and Pandora took his police car to find Prison's lare. Meanwhile, Jonathan Samuel and Lucina Angelle told to Dr. Prison that was a vehicul with plane wings that the Chipanese magic users has use magic spells flies like avians and flying machines, but Dr. Prison said that four witches and a wizard cast a magic spell on his truck and appears plane's wings. He is very furious of five Asian heroes with white arts, he thinks that Moose, Squirrel and the rest were flying with a plane-like truck. Jonathan Samuel thinking about five magic users from China/Japan who cast various spells on means of transports and flying in skies, so they get back to their lair and see Fearless Leader.
Meanwhile with the group, Hauxing and Shanying told Karen that before The Rocky and Bullwinkle Show when they met the witches always keep watching Rocky and Bullwinkle if something bad happen to them then Boris and Natasha didn't realizes that so they say they're sorry to Rocky and Bullwinkle for what they did over 51 years and they are also say they're sorry to Karen for put her under a rest. But she told them that she a marry woman about 10 years to a prison guard who took her to the movies how brave were Rocky and Bullwinkle about 15 years ago, then Karen also told Rocky, Bullwinkle , Boris and Natasha that she had a 8 year-old daughter named Pandora and they understand her. Then suddenly Zhang-Ye-Qi and Zhen-Kuei-Lin told Karen and the rest of them that they made to the lare until Fearless Leader, Prison , Jonathan and Lucina found them and capture Rocky, Bullwinkle , Karen, Fern, Boris and Natasha, so Hauxing, Shanying, Ka-Lun, Zhang-Ye-Qi and Zhen-Kuei-Lin use their magic to get help from Ole and Pandora.
When Ole and Pandora are driving looking for Karen, Hauxing, Shanying, Ka-Lun, Zhang-Ye-Qi and Zhen-Kuei-Lin appear and told them that Karen, Fern, Rocky, Bullwinkle , Boris and Natasha are in peril by Fearless Leader and Dr. Arthur Prison just like Karen's uncle is in peril. Ole remember Rocky and Bullwinkle when he was a kid just like Karen did and he also imagine that Bullwinkle got a girlfriend named Blaineley so Hauxing, Shanying and Ka-Lun show Ole and Pandora where to find Karen and others, while Zhang-Ye-Qi and Zhen-Kuei-Lin go back to Frostbite Falls to get Blaineley.
When Huaxing's cousin and Shanying's cousin finds Blaineley in Frostbite Falls they said that they've teaching kung-fu and magic by their cousins after the witches and Ka-Lun have turned Bao-Lisi, Na-Ta-Sha and Shenkyoki into stones statues and their cousins's flying squirrel wuxia teacher Master Tanshuai became ill and died for a thousands of years. Then they told Blaineley that her boyfriend and his sidekick and their x-rivals and their real world friends are in perils, Blaineley remember back at Canada she save Rocky and Bullwinkle and their three friends from ninjas now she join Zhang-Ye-Qi and Zhen-Kuei-Lin to go to the real world to save her boyfriend again. Then the witches took Blaineley to the real world with their magic once they get there Blaineley had finally meet Karen's husband, Ole and his daughter, Pandora whose told her that they all have the same problem so Blaneley, Ole, Pandora, Huaxing, Shanying, Ka-Lin, Zhang-Ye-Qi and Zhen-Kuei-Lin team up to rescue Karen, Fern, Rocky, Bullwinkle , Boris and Natasha from Dr. Prison and Fearless Leader whose going to turn Karen and her uncle into cartoons.
As Those villains have the six heroes tie up, Karen told Fearless Leader and Prison where is John Sympathy, they told her that they had him tie up by the wall, now they send Jonathan and Lucina to put Karen and Fern with their uncle now Prison use cartoon machine to transform John, Fern and Karen into a cartoon, but Boris told Fearless Leader that they can't do this to Karen, Fern and John just like 15 years ago he turn Karen, Rocky and the three FBI agents into Vegetables. So the four witches and Ka-Lun unties Rocky and Bullwinkle and free them with magic, they told them to stop that machine while they cast various spell on the HQ. Ming-Huaxing, Bei-Shanying, their old friend and their cousins cast a spell on the cartoonized Karen, Fern and their uncle and turning them back to normal just like Bullwinkle who turning the vegetalized Rocky and Karen back to normal for 15 years, they see Fern, Karen and John were find Ole and Pandora. Zhang-Ye-Qi asking her cousin kung-fu/magic mistress about Master Tanshuai's death and Zheng-Kuai-Lin and her cousin too, when Blaineley, Rocky and Bullwinkle stop the cartoon machine and unconnected it, they help Fern, Karen, John and the five magic users fights Dr. Prison , Lucina Angelle and Jonathan Samuel and defeat them with magic just like Karen, Rocky and Bullwinkle defeat Fearless Leader, Boris and Natasha for 15 years.
Boris asks to Fearless Leader that the five magic practicers, Blaineley, Sympathy, Moose and Squirrel were defeat Prisons and his two sidekicks. But Fearless Leader told him and Natasha that they're still fired for betrayed him then Ole arrested Fearless Leader, while Ming-Huaxing, Bei-Shanying and Ka-Lin laughing at Fearless Leader after he's get betrayed and fired Boris and Natasha and defeated Prisons and his sidekicks. The sorceresses ' cousins decided to cast a transformation spell just like Huaxing, Shanying and Ka-Lun's spell for 2055 years, they chants the spell in Sanskrit casting a spell on Prison and his two goons and transforms them into humanoid vegetables, then Cappy Von Trapment came and ask Karen and Fern that how proud he was for defeat Fearless Leader again then he remember John what Cappy's father, an Old Cappy Von Trapment told his son about the old FBI agents John Sympathy like his niece.
Later, Rocky, Bullwinkle , Blaineley and the five magic users were remember the whole past, Rocky meet his siblings Fury and Mia but Karen, Ole, Pandora, Fern, John, Boris and Natasha said that they didn't so Rocky told them that they would like to meet them. Ka-Lun told Karen, Ole, Pandora, Fern and John to use cartoon key to any door and that way they can see Rocky, Bullwinkle , Boris, Natasha and Blaneley any time to take cartoon adventure with them. Boris and Natasha told Rocky and Bullwinkle that they'll always be their ach-enemy, then they understand that. Then Rocky, Bullwinkle , Boris, Natasha, Blaineley, Ming-Huaxing, Bei-Shanying and theirs cousins went back to cartoon world and rejoice Captain Peachfuzz, his niece Becky, Gidney, Cloyd, Rocky's little brother, Furry and his big grumpy sister, Mia, while Karen, Ole, Pandora, Fern and John went back to Sympathy Manners along with Ka-Lun who he was invited to dinner and so they can watch any of "The Rocky and Bullwinkle Show", and as for the Narrator, he was reviewing the whole ending story as Rocky flies and draw the end in the sky just like 15 years ago.